I sit down with my co-host Reiss to break down different decentralized production models - 3D printing, mini-mills, upcycling, and bio-manufacturing - and dive deeper into the world of bio-manufacturing. We explore how biology can create much more decentralized, cleaner forms of production and discuss the following topics:
Decentralized production methods: 3D Printing, Mini Mills, Upcycling, & Bio-manufacturing.
How synthetic biology uses sugar instead of petroleum to create all types of products.
The large infrastructure gap between high-value pharmaceuticals and lower-value Industrial biotech.
Importance of “sterility” in scaling bio-manufacturing.
Using insects as living bioreactors to produce proteins.
Advancements in trait-modified crops.
What’s needed to make bio-based products cost-competitive.
Enjoy!
Watch on Youtube, Spotify or Apple Podcasts
Recording date: November 14, 2025
Chapters:
00:00 Introduction
01:30 Decentralized Production Breakdown
09:31 Explaining How Bio-manufacturing Works
12:29 Important Role Of Feedstocks
14:32 Pharma vs. Industrial Biotech
18:17 Challenges In Scaling Bio-manufacturing
23:55 Using Insects As Bioreactors
28:55 Infrastructure Needed To Make Industrial Biotech Competitive
33:06 Trait Modified Crops & Decentralized Farming
35:58 Decentralizing Crop Production
36:56 Cell-Based Chocolate Example
42:23 Scaling Laws in Industrial Biotech
51:18 Other Advancements In Crop Modification
53:18 Bio-manufacturing Wishlist
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Resources Mentioned:
California Cultured (Cell-based Chocolate/Coffee) – https://www.cacultured.com/
Remember to go direct!
Jordan
P.S. Build with love
